Create a text field with your question as its title. Then under Parameters > Validation set "Authorized input" to "Custom PERL regular expression". Then for "Perl Regular Expression" specify your REGEXP to validate the question answer. Example as follows.
Title: What is ( 1 + 1 ) * 2?
Perl Regular Expression: /^4$/
In short you'd just use /^ANSWER_HERE$/, but the answer needs to be regex safe (e.g. escape periods, etc..). See the below for REGEX information.
www.regular-expressions.info/
This is typically easy for bots to complete though once they've learned the question. I highly recommend considering using CB AntiSpam when possible.